Genetic Variation: Harmful Recessive Mutations Have Unexpected Effects on Variation
نویسندگان
چکیده
منابع مشابه
Expansion load: recessive mutations and the role of standing genetic variation.
Expanding populations incur a mutation burden - the so-called expansion load. Previous studies of expansion load have focused on codominant mutations. An important consequence of this assumption is that expansion load stems exclusively from the accumulation of new mutations occurring in individuals living at the wave front. Using individual-based simulations, we study here the dynamics of stand...
متن کاملExpansion load : recessive mutations and 1 the role of standing genetic variation 2 3 4
3 4 Stephan Peischl, Laurent Excoffier 5 6 1 Institute of Ecology and Evolution, University of Berne, 3012 Berne, Switzerland 7 2 Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland 8 9 Email addresses of authors: 10 [email protected], [email protected] 11 12 Corresponding author: 13 Stephan Peischl 14 Institute of Ecology and Evolution 15 University of Bern 16...
متن کاملUnexpected variation in lignin.
Recent studies on mutant and transgenic plants indicate that lignification may be far more flexible than previously realized. Pines with a mutation affecting the biosynthesis of the major lignin precursor, coniferyl alcohol, show a high level of an unusual subunit, dihydroconiferyl alcohol. These results argue in favor of an increased potential for genetic modification of lignin and indicate th...
متن کاملTransgenerational genetic effects on phenotypic variation and disease risk
Traditionally, we understand that individual phenotypes result primarily from inherited genetic variants together with environmental exposures. However, many studies showed that a remarkable variety of factors including environmental agents, parental behaviors, maternal physiology, xenobiotics, nutritional supplements and others lead to epigenetic changes that can be transmitted to subsequent g...
متن کاملGenetic effects on sleep/wake variation of seizures.
OBJECTIVE There is a complex bidirectional relationship between sleep and epilepsy. Sleep/wake timing of seizures has been investigated for several individual seizure types and syndromes, but few large-scale studies of the timing of seizures exist in people with varied epilepsy types. In addition, the genetic contributions to seizure timing have not been well studied. METHODS Sleep/wake timin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Biology
سال: 2020
ISSN: 0960-9822
DOI: 10.1016/j.cub.2019.11.040